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Determination of Melting Point of 3-benzyl-8-propylxanthinyl-7-acetic Acid by Capillary Method (CAT#: STEM-PPA-0049-YJL)

Introduction

Heterocyclic compounds play an important role in the metabolic process of the human body. The structures of vitamins, nucleotides and pigmented proteins are based on nitrogen-containing heterocycles (purines, pyrimidines, thiazoles, etc.). Based on the above, it is evident that these substances are used as building blocks for synthetic studies to find bioactive substances that can be used in the treatment of various pathological conditions. Many scientists pay special attention to xanthine derivatives in their studies, which are known to be natural compounds with low toxicity and wide range of significant pharmacological effects (antioxidative, diuretic, antibacterial, etc.). The introduction of carboxyl groups into the molecular structure of xanthine can significantly improve its synthetic potential. 3-benzyl-8-propylxanthine-7-acetic acid derivatives were synthesized and their physical and chemical properties were studied.




Principle

Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
The melting point measurement is usually performed in thin glass capillary tubes with an internal diameter of 1 mm and a wall thickness of 0.1 – 0.2 mm. A finely-ground sample is placed in the capillary tube to a filling level of 2 – 3 mm and introduced in a heated stand (liquid bath or metal block) in close proximity to a high accuracy thermometer. The temperature in the heating stand is ramped at a user-programmable fixed rate. The melting process is visually inspected to determine the melting point of the sample.

Applications

Chemical industry; Cosmetic/pharmaceutical industry

Procedure

1. Seal capillary.
2. Fill the sample.
3. Install the instrument.
4. Determine the melting point.

Materials

• Sample Type: crystalline compounds
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