Determination of Melting Point of 4-Substituted Semicarbazones Of Levulinic Acid by Capillary Method (CAT#: STEM-PPA-0115-YJL)

Introduction

Epilepsy is a common disorder of the central nervous system (CNS). Approximately 0.4%~1% of the population worldwide suffers from this disorder. The conventional antiepileptic drugs suffer from a range of side effects. Furthermore, the convulsions of 25% of epileptics are inadequately controlled by currently available medications. During the past decade several new drugs were approved, e.g., felbamate, fosphenytoin, gabapentin, lamotrigine, vigabatrin and zonisamide. However none of the available antiepileptic drug is ideal as they can be associated with chronic and adverse side effects. Thus the search for new anticonvulsant drugs continues to be an active area of investigation in medicinal chemistry. Aryl semicarbazones have recently acquired an im-portant place as anticonvulsants and can be consid-ered a new class of compounds with anticonvulsant activity.