Determination of Melting Point of Aceclofenac and Diclofenac with Electron Beam Radiation by Capillary Method (CAT#: STEM-PPA-0038-YJL)

Introduction

Diclofenac sodium (DC), a phenylacetic acid derivative, is the most widely used non-steroidal anti-inflammatory drug (NSAID) globally. It demonstrates anti-inflammatory, analgesic, and antipyretic properties. AC potently inhibits the cyclooxygenase enzyme (COX) involved in synthesizing prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever. It displays high permeability to penetrate synovial joints. DC and AC are indicated to relieve pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Ionizing radiation shows bactericidal properties but can also cause physicochemical changes in sterilized drugs

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Principle Applications Procedure Materials Notes Related Products

Principle

Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
The melting point measurement is usually performed in thin glass capillary tubes with an internal diameter of 1 mm and a wall thickness of 0.1 – 0.2 mm. A finely-ground sample is placed in the capillary tube to a filling level of 2 – 3 mm and introduced in a heated stand (liquid bath or metal block) in close proximity to a high accuracy thermometer. The temperature in the heating stand is ramped at a user-programmable fixed rate. The melting process is visually inspected to determine the melting point of the sample.

Applications

Chemical industry; Cosmetic/pharmaceutical industry

Procedure

1. Seal capillary.
2. Fill the sample.
3. Install the instrument.
4. Determine the melting point.

Materials

• Sample Type: crystalline compounds

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