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Determination of Melting Point of Diandrine A by Open Capillary Method (CAT#: STEM-PPA-0099-YJL)

Introduction

Plant cyclooligopeptides obtained from parts like roots, rhizomes, stems, seeds, branches, leaves, twigs, latex and fruits have received attention nowadays, due to their complex structures and wide biological spectrum including anti-inflammatory activity, cytotoxic activity, antimicrobial activity, immunosuppressive and antimalarial activity, and tyrosinase inhibitory activity. Further, plant-derived cyclic peptides play a vital role in drug design and have provided significant promise for future endeavors. A natural cyclopolypeptide, diandrine A, was isolated from whole plants of Drymaria diandra (Caryophyllaceae) having selective inhibitory effect on collagen-induced platelet aggregation.

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Principle Applications Procedure Materials

Principle

Melting point is a characteristic property of solid crystalline substance. It is the temperature at which the solid phase changes to the liquid phase. This phenomenon occurs when the substance is heated.
In all major pharmacopoeias the open capillary method is described to determine the melting point (slip point) for fats, fatty acids, paraffin, and waxes. In a glass capillary tube open at both ends (1), 10 mm of sample is introduced (2), chilled to a given temperature and immersed into a water bath (3/4). The melting point with open capillary, also known as slip point or slip melting point, is the temperature at which the substance begins to rise in the capillary due to the effect of the increasing temperature and buoyancy.

Applications

Chemical industry; Cosmetic/pharmaceutical industry

Procedure

1. Prepare the substance.
2. Affix one of the capillaries to a thermometer.
3. Place the thermometer with an affixed capillary into a glass.
4. Increase the temperature.

Materials

• Sample Type: crystalline compounds

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