Determination of Melting Point of Fluconazole Ocuserts by Capillary Method (CAT#: STEM-PPA-0056-YJL)

Introduction

Fluconazole, a synthetic antifungal agent, is a triazole derivative used in the treatment of a wide range of fungal infections and it belongs to class II of biopharmaceutical classification system (BCS) having low water solubility. Fluconazole is a prescription drug indicated for the treatment and prophylaxis of fungal infections where other antifungals have failed or are not tolerated (e.g. due to adverse effects), including Candidiasis caused by susceptible strains of Candida, Tinea corporis, Tinea cruris or Tinea pedis, Onychomycosis and Cryptococcal meningitis.
Melting point determination of the drug sample was done; as it is a first indication of purity of the sample. The presence of relatively small amount of impurity can be detected by lowering as well as widening in the melting point range.