Determination of Melting Point of Ondansetron Hydrochloride by Open Capillary Method (CAT#: STEM-PPA-0100-YJL)

Introduction

Nasal route for drug delivery is the route which has been utilized from ancient times for recreational purpose. The main advantage of this route is the presence of highly permeable monolayer epithelium and rich vascularised submucosa, which is responsible for fast and complete absorption of drugs, mainly lipophilic in nature. By this route hepatic first pass metabolism is avoided and also drug can be easily administered to brain by crossing blood brain barrier, but the main drawback of these routes is that a very low volume can be instilled (0.25 to 0.5 ml) in droplet form therefore drug loading becomes a major problem in exploring and utilizing this route. Another major problem faced by this route is the rapid mucocilliary clearance of xenobiotic. The pH of the nasal cavity is around 5.5 - 6.5 and at this pH both of these drugs are slightly soluble.