Determination of Melting Point of Paracetamol by Open Capillary Method (CAT#: STEM-PPA-0066-YJL)

Introduction

The increase in the aqueous solubility and physicochemical property of insoluble and slightly soluble drugs is of major concern in pharmaceutical formulations.
Co-crystals incorporate pharmaceutically acceptable guest molecules into a crystal lattice along with the API. Co-crystals have regained attention as attractive alternate solid forms for drug development. Physiochemical properties of pharmaceuticals can be improved by obtaining co-crystals using cocrystallization. Cocrystals with the same active pharmaceutical ingredient will have strikingly different pharmaceutical properties (melting point, solubility, dissolution, bioavailability, moisture uptake, chemical stability, etc.) depending on the nature of the second component.
Paracetamol is is a non-steroidal anti-inflammatory drug It is commonly used for the relief of headaches, and other minor aches and pains, and is a major ingredient in numerous cold and flu remedies having very slightly soluble in cold water.