Determination of Melting Point of Prasugrel by Capillary Method (CAT#: STEM-PPA-0043-YJL)

Introduction

Prasugrel is a thienopyridinic compound approved in 2009 by Food and Drug Administration (FDA) for the management of acute coronary syndromes and in patients undergoing percutaneous coronary intervention. The synthesis of racemic mixture is common but the coated tablets containing prasugrel were marketed in the hydrochloride form due its better hydrolytic stability and satisfactory solubility in physiological pH. Prasugrel hydrochloride is a white to light brown crystalline solid and slightly hygroscopic.
There are methods that provide important physicochemical information for identification and structural elucidation of reference standards, ensuring their characterization for further analysis of drugs present in pharmaceuticals. Melting range is a physical test employed to identify chemical substances such as drugs.