Determination of Melting Point of Some Thiazolidine-2, 4-Dione Derivatives by Open Capillary Method (CAT#: STEM-PPA-0103-YJL)

Introduction

Diabetes mellitus, long considered a disease of minor significance to world health, is now taking its place as one of the main threats to human health in the 21st century. The incidence of the disease currently is estimated to reach 210 million by the year 2010 and 300 million by the year 2025 1 . Most cases will be of type 2 diabetes, which is strongly associated with a sedentary life style and obesity. Early stages of type 2 diabetes mellitus (Type 2 DM) are characterized by tissue resistance to the effects of insulin secreted by pancreatic beta cells. The ability of pancreatic beta cells to continue increased production of insulin diminishes over time. Since the pioneer thiazolidinedione compound, ciglitazone, was reported improving blood glucose level by increasing insulin sensitivity, several new Thiazolidine-2, 4-diones such as pioglitazone, rosiglitazone, was launched into market since 1997.