DMPK Analysis Service Based on UPLC-MS/MS

STEMart offers specialized DMPK (Drug Metabolism and Pharmacokinetics) Analysis Services using UPLC-MS/MS (Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry), a state-of-the-art technology that provides precise and detailed analysis of drug metabolism and pharmacokinetics. In our laboratory, UPLC-MS/MS plays a critical role in delivering high-resolution data on drug absorption, distribution, metabolism, and excretion (ADME). This technology is essential for drug development, helping to ensure that compounds meet the necessary safety and efficacy standards before advancing to clinical trials.

UPLC-MS/MS operates by combining ultra-performance liquid chromatography, which allows for rapid and efficient separation of compounds, with tandem mass spectrometry, which provides sensitive and specific detection of analytes. This technology is particularly effective in DMPK studies, where accurate quantification of drugs and their metabolites in biological matrices is crucial. UPLC-MS/MS is widely applied in pharmaceutical research, supporting drug discovery, optimization, and regulatory submission processes.

Leveraging our expertise in mass spectrometry and the advanced capabilities of UPLC-MS/MS, STEMart offers a comprehensive range of DMPK analysis services tailored to meet the specific needs of our clients. From metabolic stability studies to detailed pharmacokinetic profiling, our services provide the high-quality data necessary to advance your drug development projects.

What We Offer

• Pharmacokinetic Profiling

We offer comprehensive PK profiling using UPLC-MS/MS, analyzing drug absorption, distribution, metabolism, and excretion to support drug development and optimize dosing regimens.

• Metabolic Stability Studies

Our service includes assessing the metabolic stability of drug candidates, providing insights into the potential for metabolic liabilities and guiding drug design.

• Drug-Drug Interaction Studies

We investigate potential drug-drug interactions using UPLC-MS/MS, analyzing the impact of co-administered drugs on the metabolism of the test compound.

• Bioanalytical Method Development

We develop and validate bioanalytical methods for the quantification of drugs and metabolites in various biological matrices, ensuring reliable and reproducible results.

Why Choose Us

• High Sensitivity and Resolution

Our UPLC-MS/MS system offers high sensitivity and resolution, ensuring accurate detection and quantification of drugs and metabolites, even in complex biological samples.

• Comprehensive DMPK Analysis

We provide extensive coverage of DMPK parameters, offering a complete understanding of drug behavior in the body, which is essential for successful drug development.

• Regulatory Compliance

Our DMPK analysis services are conducted in accordance with regulatory guidelines, ensuring that your data meets the stringent requirements for drug approval.

• Experienced Team

Our team of experts provides guidance and support throughout your project, delivering high-quality data and insights to advance your research and development efforts.

Our Equipment

UPLC-MS/MS

This advanced system combines ultra-performance liquid chromatography with tandem mass spectrometry, providing rapid, sensitive, and accurate analysis of drugs and metabolites in biological matrices.

Triple Quadrupole MS

Complementing our UPLC-MS/MS, this instrument delivers targeted quantification with high sensitivity and specificity, essential for accurate DMPK studies.

Nano-LC-MS/MS

This nano-scale liquid chromatography system coupled with tandem mass spectrometry enhances the sensitivity of our DMPK assays, making it ideal for analyzing low-abundance compounds.

STEMart provides high-quality mass spectrometry services tailored to meet the specific needs of our clients. Our experienced specialists use advanced equipment and follow strict quality control measures to ensure accurate and reliable results. Contact us to learn more about our mass spectrometry services and how we can help you achieve your research goals.