Drug Pharmacokinetic Studies

Pharmacokinetic studies are a type of study that examine the absorption, distribution, metabolism, and excretion of a drug in the body. Pharmacokinetic studies are important in determining how a drug behaves in the body, how it is processed, and how long it remains active. They also can help identify potential drug interactions that may affect how a drug is metabolized or eliminated from the body. Pharmacokinetic studies are an important component of drug development, which ultimately helps improve drug safety and efficacy.

Pharmacokinetic studies are typically conducted in both preclinical and clinical settings to assess the pharmacokinetic profile of a drug. Traditionally, animal models are used in preclinical studies to assess the pharmacokinetics of a drug. While animal studies are always expensive due to the need for specialized facilities, equipment, and trained personnel. Microfluidic platforms are highly automated and reduce the need for large quantities of expensive drugs or biological samples, making them a more cost-effective approach to conduct pharmacokinetics studies.

What We Can Do for You

STEMart can utilize a variety of microfluidics technologies to help customers complete pharmacokinetics studies:

• Drug distribution studies
  • Study the distribution of drug in various tissues and organs, including the brain, lungs, liver, and kidneys.
  • Study the factors that influence the drug distribution, including blood flow to different tissues, protein binding, permeability of cell membranes and drug affinity for certain tissues or organs.
  • Investigate how drug carriers (such as nanoparticles, liposomes, or microparticles) interact with biological tissues and cells to help customer optimize drug delivery strategies for enhanced drug efficacy.
• Drug absorption studies
  • Study how drugs are absorbed in a simulated gastrointestinal tract.
  • Study how drugs are transported across biological barriers such as the blood-brain barrier or the intestinal epithelium.
• Drug metabolism studies
  • Separate and analyze metabolites generated during drug metabolism to identify the metabolic pathway involved in drug metabolism and potential biomarkers for drug efficacy and toxicity.
  • Monitor drug metabolism in real time to track the kinetics of metabolite formation and quantify the efficiency of metabolic pathways.
  • Investigate how different drugs interact with each other in terms of metabolism to identify potential drug-drug interactions and optimize dosing regimens.
• Drug excretion studies
  • Study the excretion of drugs by the kidney with kidney-on-a-chip and evaluate the impact of various factors, such as drug properties and renal disease, on drug excretion.
  • Study the excretion of drugs by the liver with liver-on-a-chip and investigate the effects of hepatic drug metabolism on drug excretion.

For more information about our drug pharmacokinetic studies service, please contact us.