Electron paramagnetic resonance (EPR) imaging (CAT#: STEM-MB-1038-WXH)

Introduction

EPR imaging provides a valuable clinical tool for the three-dimensional mapping of the spatial distribution of paramagnetic species. It can be used to map tissue oxygenation and the spatial distribution of free radicals in large tissue samples, whole animals or parts of the human body that can be conveniently placed in the imaging devices, like hands or feet.

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Principle Applications Procedure Materials Notes Related Products

Principle

Electron Paramagnetic Resonance (EPR), also called Electron Spin Resonance (ESR), is a branch of magnetic resonance spectroscopy which utilizes microwave radiation to probe species with unpaired electrons, such as radicals, radical cations, and triplets in the presence of an externally applied static magnetic field.
EPR spectroscopy is particularly suitable for the investigation of (bio)chemical systems with strongly localized spin density and their interaction with the environment. For these systems EPR provides information on the structure and dynamics and is widely used in chemistry, physics and biology.

Applications

• Imaging of tissue oxygenation in general
• Cardiac research
• Drug delivery research
• Dermatology (specifically in melanoma research)
• Monitoring of infection pathways

Procedure

1. Sample Preparation
2. Electron paramagnetic resonance (EPR) spectroscopy testing
3. Data analysis

Materials

• EPR Spectrometer
• Spectrophotometer

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