Fragment-Based Drug Screening NMR Service Based on 500 MHz Spectrometer

STEMart offers a specialized Fragment-Based Drug Screening NMR Service using advanced 500 MHz spectrometers, including the Bruker Avance III HD 500 MHz and JEOL ECZ500R 500 MHz systems. These high-performance instruments enable our laboratory to conduct precise and efficient fragment-based screening, identifying promising molecular fragments that interact with drug targets. Our service provides detailed insights into molecular interactions and binding affinities, supporting the early stages of drug discovery and lead optimization.

Our 500 MHz NMR systems operate on nuclear magnetic resonance principles, allowing for sensitive detection of small molecule fragments binding to target proteins. Techniques like Saturation Transfer Difference (STD) and WaterLOGSY enable us to observe weak binding interactions, essential for fragment-based drug design. Widely applied in medicinal chemistry, pharmacology, and structural biology, fragment-based screening via NMR is a reliable and non-invasive method for identifying potential drug candidates.

Leveraging our state-of-the-art 500 MHz spectrometers and expertise in fragment-based screening, STEMart offers a comprehensive suite of services, including fragment binding analysis, affinity ranking, and binding site identification. Our services empower researchers to accelerate drug discovery by providing robust, high-quality data on molecular interactions, essential for developing effective therapeutic agents.

What We Offer

• Fragment Binding Analysis

Detailed NMR analysis to detect fragment binding to target proteins, supporting early-stage drug discovery and the identification of potential lead compounds.

• Affinity Ranking of Fragments

Provides quantitative ranking of fragment affinities, enabling the prioritization of candidates with the strongest interactions.

• Binding Site Identification

Identifies binding sites on target proteins, offering insights into binding mechanisms that guide lead optimization and drug design.

• Chemical Shift Mapping

Monitors chemical shifts upon fragment binding, aiding in understanding molecular interactions and structural effects on the target.

Why Choose Us

• High Sensitivity for Low-Affinity Interactions

Our 500 MHz spectrometers provide high sensitivity, crucial for detecting weak binding events that are common in fragment-based drug discovery.

• Experienced Drug Discovery Team

Our NMR specialists have extensive expertise in fragment-based screening, ensuring accurate interpretation and reliable data for drug discovery.

• Customizable Data Reporting

We offer flexible reporting formats, providing clear, precise data that supports informed decision-making in drug development.

• Rapid Turnaround for Accelerated Research

Our streamlined processes ensure fast, high-quality results, helping researchers progress efficiently through drug screening stages.

Our Resources

Bruker Avance III HD 500 MHz NMR

The Bruker Avance III HD 500 MHz spectrometer delivers high-resolution spectra essential for fragment-based drug screening. Equipped with advanced probe technology, it enables sensitive detection of low-affinity binding interactions, supporting efficient drug discovery.

JEOL ECZ500R 500 MHz NMR

This 500 MHz NMR system from JEOL provides high sensitivity and precision, ideal for identifying fragment-target interactions. Its robust capabilities and reliability make it a valuable asset in early-stage drug screening and affinity ranking studies.

STEMart provides high-quality NMR services tailored to meet the specific needs of our clients. Our experienced specialists use advanced equipment and follow strict quality control measures to ensure accurate and reliable results. Contact us to learn more about our NMR services and how we can help you achieve your research goals.