Human Recombinant IP-10 (CXCL10), STEMCELL Technologies (CAT#: STEM-CT-0923-ZJF)

Interferon gamma-inducible protein (IP) 10 or CXCL10 is a member of the CXC chemokine family. It binds CXCR3 activating ERK1/2, p38/MAPK, JNK, and PI3-kinase/AKT signaling pathways, inducing intracellular calcium influx, DNA synthesis, cell proliferation, and chemotaxis. IP-10 regulates innate and adaptive immune responses by affecting the function of activated T cells, natural killer cells, inflammatory dendritic cells, macrophages, and B cells. IP-10 is produced by leukocytes, activated neutrophils, eosinophils, monocytes, epithelial cells, endothelial cells, fibroblasts, and keratinocytes in response to IFN-gamma. IP-10 has been implicated in a wide range of diseases, including infectious diseases and chronic inflammatory and autoimmune diseases, as well as in tumor formation (Liu et al.).

Subtype: Cytokines
Alternatives Names: 10 kDa interferon-gamma-induced protein, C7, crg-2, Chemokine (C-X-C motif) ligand 10, CXCL10, Gamma-IP-10, gIP-10, IFI10, INP10, mob1, SCYB10, Small inducible cytokine B10
Cell Type: Monocytes, T Cells
Species: Human
Area of Interest: Immunology
Molecular Weight: 8.8 kDa
Purity: ≥ 95%

Reliable Consistency: Guarantees uniformity and repeatability in various applications with endotoxin levels below 0.2 EU/μg.
Free of Animal Components: Completely devoid of any animal or human-derived elements.
Broad Selection: Offers a wide range of human, mouse, and rat cytokines available in multiple sizes.

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