Human Recombinant R-Spondin-3, STEMCELL Technologies (CAT#: STEM-CT-0790-ZJF)

R-Spondin-3 is a member of thrombospondin type 1 repeat (TSR-1) superfamily that is involved in the canonical Wnt/β-catenin signaling pathway (de Lau et al.). R-spondin proteins are characterized by two furin-like repeats at the amino terminus and thrombospondin domain located near the carboxyl terminus (de Lau et al.). R-spondin-3 expression is associated with ovarian cancer (Gu et al.), prostate cancer (Mesci et al.), and differentiation of intestinal epithelial cells in diabetes mellitus (Shan et al.). In a transgenic mice model, the expression of R-Spondin-3 induces the expansion of Lgr5+ stem cells, Paneth cells, and Lgr4+ cells, promoting the intestinal stem cell compartment (Hilkens et al.). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain.

Alternatives Names: Cristin 1, hRspo3, PWTSR, R-Spondin 3, Roof plate-specific spondin-3, RSPO3, RSpondin 3, Thrombospondin type-1 domain-containing protein 2, THSD2
Cell Type: Epithelial Cells
Species: Human
Area of Interest: Organoids, Stem Cell Biology
Purity: ≥ 93%

Reliable Consistency: Guarantees uniformity and repeatability in various applications with endotoxin levels below 0.2 EU/μg.
Free of Animal Components: Completely devoid of any animal or human-derived elements.
Broad Selection: Offers a wide range of human, mouse, and rat cytokines available in multiple sizes.

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