Humanized Mouse Model Service Based on Xenografting Techniques

STEMart provides a highly specialized Humanized Mouse Model Service utilizing xenografting techniques to engraft human cells or tissues into immunocompromised mice. This service allows for the creation of humanized models that mimic human physiology and immune systems, providing an invaluable tool for studying human diseases in vivo. Our laboratory is equipped with advanced xenografting technologies that enable the precise and efficient engraftment of human cells, allowing for accurate and reproducible results in research fields such as oncology, immunology, and infectious diseases.

Xenografting is the process of transplanting human cells, tissues, or organs into mice that have been engineered to accept foreign tissues. This technique is particularly useful for studying tumor growth, immune responses, and human-specific diseases in a controlled environment. Humanized mouse models generated through xenografting have become an essential tool in preclinical research, particularly for the development of immunotherapies and the study of cancer biology.

Leveraging our advanced xenografting techniques and expert team, we offer a range of services that cater to the diverse needs of researchers. From human tumor xenografts to immune system reconstruction models, our humanized mouse services are designed to support cutting-edge research in drug development, biomarker discovery, and disease mechanism studies.

What We Offer

• Human Tumor Xenograft Service

Establishment of human tumor xenografts in immunocompromised mice to study tumor biology, metastasis, and therapeutic responses.

• Immune System Reconstruction Service

Humanizing the mouse immune system by engrafting human hematopoietic stem cells or peripheral blood mononuclear cells (PBMCs) for immunology studies.

• Patient-Derived Xenograft (PDX) Service

Creating patient-derived xenografts by implanting tumor tissues from cancer patients into mice, providing a highly relevant model for personalized cancer research.

• Infectious Disease Model Service Based on Humanized Mice

Utilizing humanized mouse models to study human-specific infections and immune responses, aiding in the development of antiviral or antibacterial therapies.

• Pharmacokinetics and Drug Efficacy Testing in Humanized Models

Evaluation of drug pharmacokinetics and therapeutic efficacy in humanized mouse models to simulate human responses in preclinical studies.

Why Choose Us

• Highly Accurate Models

Our xenografting techniques produce humanized mouse models that closely replicate human disease biology, leading to more reliable and translatable results.

• Comprehensive Range of Models

We offer diverse humanized models, including immune system reconstruction and patient-derived xenografts, tailored to your specific research needs.

• State-of-the-Art Xenografting Facilities

Equipped with cutting-edge instruments, our lab ensures high success rates in human cell engraftment, providing consistent and reproducible models.

• Expert Technical Support

Our team of experienced scientists provides full support throughout your project, from model design to data interpretation, ensuring optimal outcomes.

Our Resources

Xenografting Platform (Charles River CRISPR-Ready NOG Mice)

We use CRISPR-ready NOG mice from Charles River, which are specifically designed for xenografting applications, enabling reliable human cell engraftment.

Microinjector System (Narishige IM300)

This precision microinjector allows for the accurate delivery of human cells or tissues into mouse models, ensuring efficient xenograft establishment.

In Vivo Imaging System (PerkinElmer IVIS Spectrum)

The IVIS Spectrum system from PerkinElmer enables non-invasive imaging of xenografted tissues, allowing real-time monitoring of tumor growth and treatment responses.

STEMart provides high-quality animal model services tailored to meet the specific needs of our clients. Our team of experienced specialists utilizes cutting-edge equipment and adheres to rigorous quality control protocols, ensuring precise and dependable results. Contact us to learn more about our animal model services and how we can help you achieve your research goals.