IL-17 Detection (CAT#: STEM-MB-0284-WXH)

Introduction

IL-17 is secreted by CD4+T cells, and can induce epithelial cells, endothelial cells, and fibroblasts to synthesize and secrete IL-6, IL-8, G-CSF, and PGE2, and promote the expression of ICAM-1. These molecules have different functions in different stages of hematopoiesis, inflammation, and immunity. The interleukin 17 family contains six member ligands (IL-17A ~ IL-17F) and five receptors (IL-17RA ~ IL-17RD and SEF). IL-17 is an inflammatory cytokine produced primarily by activated T cells. Among them, IL-17A has strong inflammatory properties, it can promote the local production of chemokines and stimulate the production of IL-6 and PGE-2.Besides, it can also enhance local inflammation and induce intercellular adhesion molecules on the cell surface (intercellular adhesion molecules, ICAM), which drives the response of T cells. IL-17E also has strong pro-inflammatory effects in vitro and in vivo. Other new members of the IL-17 family have distinctly different expression forms, and therefore may have different biological effects.