IL-26 Detection (CAT#: STEM-MB-0293-WXH)

The active receptor complex of IL-26 is a dimer composed of IL-20R1 and IL-10R2, both class II cytokine receptors, with IL-20R1 expressed mainly in non-hematopoietic cells, especially epithelial cells, but not in lymphocytes, whereas IL-10R2 is widely expressed in various tissues. IL-20R1 is the main ligand-binding chain, which associates with Jak1, and the ligand checkpoint causes the initiation of a signal transduction cascade. il-10r2 associates with tyrosine protein kinase 2 (Tyk2), and the receptor-associated Jaks cross-activate and phosphorylate IL-20R1 intracellular domain, which activates STAT1 and STAT3.

IL-26 has been associated with inflammatory bowel disease and can participate in processes that regulate inflammation and immune responses.
IL-26 effectively promotes the recruitment of neutrophils to the focus of infection and exerted a bactericidal effect.

1. Process samples.
2. IL-26 detection (qPCR, Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.

Sample Types-Blood, serum, plasma, cerebrospinal fluid, cell culture supernatant, tissue homogenate, cell culture medium, urine, tumor, etc.