IL-37 Detection (CAT#: STEM-MB-0303-WXH)

IL-37b is able to bind to IL-18Rα or IL-8 binding protein. However, IL-37b has a slightly higher affinity for IL-8BP, and binding of IL-37 to IL-18BP enhances IL-18BP's ability to inhibit IL-18, thereby prohibiting IFN-γ production and T-cell proliferation. IL-37 can also enter the nucleus and bind to Smad3 and inhibits the transduction of various signaling pathways, such as the phosphorylation of signal transducers and activators of transcription (STAT) 1-4, p38 mitogen-activated protein kinase (MAPK), amino-terminal kinase c-Jun (JNK) signaling pathway, thereby reducing the production of IL-1α, IL-1β, IL-6, IL-8, and TNF-α. The combination of IL-37 and Smad3 also enhances the biological role of the cytokine TGF-β, which promotes bone repair. So there is a relationship between IL-37 and bone repair.

IL-37 is related to many diseases.
IL-37 inhibits excessive immune response through negative feedback during the onset of rheumatoid arthritis.
IL-37 can inhibit excessive inflammation in autoimmune diseases and protect the body itself, so it has a certain relationship with Crohn's disease, lupus erythematosus and other diseases.
IL-37 can counteract the effects of pro-inflammatory cytokines and promote the further development of obesity.
IL-37 can play an anti-inflammatory effect, inhibiting the occurrence of septic shock.

1. Process samples.
2. IL-37 detection (qPCR, Enzyme-linked immunosorbent assay (ELISA), Flow cytometry).
3. Analysis results.

Sample Types-Blood, serum, plasma, cerebrospinal fluid, cell culture supernatant, tissue homogenate, cell culture medium, urine, tumor, etc.