Immunotherapy Service Based on PD-1/PD-L1 Knockout Mice

STEMart offers an advanced Immunotherapy Service using PD-1/PD-L1 knockout mice to evaluate immune checkpoint inhibitors and other immunotherapies. PD-1/PD-L1 knockout models allow researchers to explore the role of these immune checkpoint pathways in regulating tumor immune evasion. Our laboratory employs state-of-the-art gene editing tools to create PD-1/PD-L1 knockout mice, providing a reliable platform for studying immune responses and developing new cancer therapies.

PD-1 (Programmed Death-1) and its ligand PD-L1 are critical regulators of immune responses, particularly in the context of tumor immunology. When these molecules are knocked out in mice, the immune system’s ability to detect and destroy cancer cells is enhanced, making this model highly relevant for evaluating immunotherapies like checkpoint inhibitors. These knockout mice are invaluable for oncology, immunology, and pharmacology research, offering insights into how immune therapies can overcome tumor immune suppression.

Leveraging our expertise in gene editing and immunology, we offer a range of services that support immunotherapy research. Our PD-1/PD-L1 knockout mouse models are designed to help researchers study immune responses in cancer, autoimmune diseases, and chronic infections. With our comprehensive support, we provide customized solutions for evaluating the effectiveness and mechanisms of novel immunotherapeutic agents.

What We Offer

• PD-1 Knockout Mouse Model Development

Creation of mice lacking PD-1 expression to evaluate immune checkpoint inhibitors and study tumor immune responses.

• PD-L1 Knockout Mouse Model Service

Generation of PD-L1 knockout mice for research into immune evasion mechanisms and the development of anti-PD-L1 therapies.

• Tumor Growth and Immune Response Analysis

Comprehensive evaluation of tumor growth and immune response in PD-1/PD-L1 knockout mice, providing critical data for immunotherapy development.

• Combination Immunotherapy Studies

Investigation of combination therapies using PD-1/PD-L1 knockout models to assess synergistic effects of multiple immunotherapeutic agents.

• Cytokine Profiling and Immune Cell Monitoring

Analysis of cytokine production and immune cell infiltration in tumors to assess immune activity in knockout models.

Why Choose Us

• Advanced Knockout Models

Our PD-1/PD-L1 knockout mice provide highly accurate models for studying the mechanisms of immune evasion and the efficacy of checkpoint inhibitors.

• Expert Immunotherapy Support

Our team of immunology experts offers full support from model creation to data analysis, ensuring comprehensive and accurate study results.

• Customizable Study Designs

We offer flexible study designs tailored to meet your specific immunotherapy research needs, from single-agent studies to combination therapy testing.

• State-of-the-Art Facilities

Our laboratory is equipped with cutting-edge gene editing tools and immunological assays, ensuring precise and reliable knockout model creation.

Our Resources

CRISPR-Cas9 Gene Editing Platform

Our CRISPR-Cas9 system from Thermo Fisher enables precise knockout of the PD-1/PD-L1 genes, ensuring accurate genetic modifications for immunotherapy research.

Flow Cytometry System (BD FACSCanto II)

This system is used to monitor immune cell populations and cytokine production in PD-1/PD-L1 knockout mice, providing detailed insights into immune responses.

In Vivo Imaging System (PerkinElmer IVIS Spectrum)

The IVIS Spectrum system allows for real-time, non-invasive imaging of tumor growth and immune responses, making it ideal for tracking immunotherapy outcomes.

STEMart provides high-quality animal model services tailored to meet the specific needs of our clients. Our team of experienced specialists utilizes cutting-edge equipment and adheres to rigorous quality control protocols, ensuring precise and dependable results. Contact us to learn more about our animal model services and how we can help you achieve your research goals.