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In Vivo Pharmacodynamic Evaluation of A498 Cell Line Based Kidney Cancer (CAT#: STEM-AE-0057-LGZ)

Introduction

Kidney cancer is a malignant tumor originating from the renal parenchymal urinary tubular epithelial system. Various subtypes of renal cell carcinoma originating in different parts of the urinary tubules were included, but tumors originating in the renal interstitial and renal pelvis were excluded. The main types of cancer cells were clear cell carcinoma, granular cell carcinoma and undifferentiated carcinoma, among which clear cell carcinoma was the most common. Clear cell carcinoma has a large volume, clear edges, polygonal shape, small, uniform nuclei, and deep staining. The cells are often arranged in sheets, papillaries, or tubes.




Principle

In vivo activity is the gold standard for the evaluation of drug biological activity, and it is the first verification of non-human comprehensive activity. In vivo pharmacodynamic evaluation plays a decisive role in the confirmation of candidate molecules and the screening of clinical target indications, and is an indispensable link in the development of new drugs. We provide a variety of disease animal models including inflammation, immunity, metabolism, etc., to meet the needs of different new drug research and development projects of customers, and accept customized services.
In vivo pharmacodynamic evaluation, as the basic research of new drugs, is carried out on animals. It is to verify the effect of drugs with the comprehensive participation of a number of other factors, and to understand the effect of drugs on a certain part of the body by comparing and analyzing the animal signs, in vitro organs, blood components, histone expression and tissue changes before and after drug administration.

Applications

Kidney Cancer

Procedure

1. Disease model construction.
2. Mice dosing.
3. Efficacy monitoring.
4. Biochemical detection of tissue samples.

Materials

• Sample Type: liquid or powder

Notes

Oncology efficacy Service package:
In vivo syngeneic model
In vivo CDX model
In vivo PBMC humanized model
In vivo transgenic mouse model
In vivo orthotropic or Metastasis tumor model
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