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Rheumatoid Arthritis (RA) is one of the most common autoimmune diseases of human beings. Its main clinical symptoms include joint swelling, pain and movement disorders, etc. The disease is extremely serious and may even lead to disability. The main pathological manifestations were hypertrophic synovitis, cartilage injury and bone structure destruction. In order to better study human rheumatoid arthritis, researchers have developed a variety of animal models in mice that can simulate human rheumatoid arthritis, among which collagen-induced arthritis can best reflect the clinical and pathological characteristics of human rheumatoid arthritis.