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Microfluidics for Microbial Research

Microorganisms are found in almost all types of environments on earth. Through playing a critical role in geochemistry and ecosystem, they have a profound influence on agriculture, industry, global climate and human health conditions. The microbial research will undoubtedly improve the quality of our lives. Traditional culture-independent and culture-based approaches for microbial research suffer from inherent shortcomings like low-throughput, labor-intensive, and high-cost. To overcome the limitations of traditional technologies, microfluidics is one of the new technologies that have shown its prominence in greatly advancing the field of microbiome research.

Microfluidics Techniques for Microbial Research

  • Droplet microfluidics
    • Droplet microfluidics provides hundreds of thousands to millions of segregated environments in micrometer-size for independent encapsulation, cultivation, microscopy examination, phenotypes or genotypes detection, and handling of single or few targeted microbial cells.
  • Microwell microfluidics
    • Microwell microfluidics features an open geometry which allows easy addition and removal of reagent and cells, making it suitable for handling complex tasks that require multi-step parallel processing.

Advantages of Microfluidics Applied for Microbial Research

  • High throughput
  • Low cost
  • Feasibility of integrating with various devices for monitoring of phenotypic and genotypic features of microbes

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