mTOR Signaling Pathway Luminex Assay (CAT#: STEM-MB-0351-WXH)

Introduction

The mammalian target of rapamycin (mTOR) is a key protein evolutionarily conserved from yeast to man and is essential for life. The mTORC1 complex is made up of mTOR, Raptor, mLST8, and PRAS40, and the mTORC2 complex is composed of mTOR, Rictor, Sin1, and mLST8.
mTOR signaling pathway serves as a master regulator of cell metabolism, growth, proliferation and survival. mTORC1 positively regulates cellular metabolism and ATP production, as well as controlling the synthesis of lipids for membrane generation in proliferating cells and promoting cellular growth by negatively regulating autophagy. Aberrant mTOR signaling is involved in many pathological conditions including cancer, cardiovascular disease, diabetes, obesity, and neurodegeneration. Thus, mTOR inhibitor use in treating solid tumors, rheumatoid arthritis, coronary restenosis, organ transplantation, and other diseases is growing and increasing our knowledge of the role of the mTOR pathway in health, disease, and aging.