Neurodegenerative Disease Service Based on Drosophila Alzheimer's and Parkinson's Models

STEMart offers a specialized Neurodegenerative Disease Service utilizing Drosophila models of Alzheimer’s and Parkinson’s diseases to study the underlying mechanisms of neurodegeneration and evaluate potential therapeutic compounds. Our laboratory is equipped with advanced genetic tools and behavioral monitoring systems that allow us to replicate human neurodegenerative conditions in fruit flies. These models enable researchers to explore disease progression, identify molecular targets, and test the efficacy of drug candidates in a cost-effective and high-throughput manner.

In our Drosophila models, neurodegenerative diseases are induced by expressing human disease-associated genes, such as amyloid beta and tau for Alzheimer’s, and alpha-synuclein for Parkinson’s. These models mimic key features of human neurodegenerative diseases, including protein aggregation, neuronal loss, and motor dysfunction. Our platform provides a powerful and efficient means to investigate genetic interactions, study disease pathways, and perform drug screenings in the context of neurodegenerative disease.

Leveraging our expertise in Drosophila neurodegeneration models, we offer a wide range of services that support research into the pathology and treatment of neurodegenerative diseases. Our Drosophila-based systems allow for high-throughput screening of genetic modifiers and therapeutic compounds, providing rapid insights into disease mechanisms and potential therapeutic interventions.

What We Offer

• Alzheimer’s Disease Model Service

Using Drosophila models expressing amyloid beta or tau, we replicate Alzheimer's pathology for studying neuronal degeneration and testing potential therapies.

• Parkinson’s Disease Model Service

We use alpha-synuclein-expressing Drosophila to study the mechanisms of Parkinson’s disease and evaluate compounds that can mitigate motor dysfunction and neurodegeneration.

• Genetic Modifier Screening Service

High-throughput screening of genetic modifiers in Drosophila neurodegenerative disease models to identify novel genes that influence disease progression.

• Drug Screening and Efficacy Testing

Evaluation of therapeutic compounds in Drosophila models to assess their ability to prevent or reverse neurodegeneration and motor impairments.

• Behavioral and Motor Function Analysis

Monitoring of Drosophila behavior, motor function, and survival to track disease progression and therapeutic effects in neurodegenerative models.

Why Choose Us

• Genetically Accurate Models

Our Drosophila models accurately replicate key features of human neurodegenerative diseases, providing a reliable system for studying disease mechanisms.

• High-Throughput Screening

Our automated systems allow for rapid, large-scale genetic and drug screenings, enabling faster identification of potential treatments and genetic targets.

• Cost-Effective Research

Drosophila models offer a more economical alternative to mammalian systems, allowing for efficient drug discovery and preclinical research.

• Comprehensive Disease Modeling

We provide both Alzheimer’s and Parkinson’s disease models, allowing for comparative studies and a broader understanding of neurodegenerative processes.

Our Resources

Genetic Manipulation System (FlyBase UAS-GAL4 System)

The FlyBase UAS-GAL4 system allows for precise genetic manipulation in Drosophila, enabling controlled expression of human neurodegenerative genes for Alzheimer’s and Parkinson’s modeling.

Automated Behavioral Monitoring System (Noldus EthoVision XT)

Our EthoVision XT system tracks locomotor activity and behavior in Drosophila, providing accurate measurements of motor function and behavioral decline in neurodegenerative models.

High-Throughput Screening System (PerkinElmer Opera Phenix)

The PerkinElmer Opera Phenix system enables large-scale genetic and drug screening, providing rapid identification of potential treatments and genetic modifiers in Drosophila models.

STEMart provides high-quality animal model services tailored to meet the specific needs of our clients. Our team of experienced specialists utilizes cutting-edge equipment and adheres to rigorous quality control protocols, ensuring precise and dependable results. Contact us to learn more about our animal model services and how we can help you achieve your research goals.