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Omentin protein is a recently discovered new adipocytokine produced mainly by secretions from visceral adipose tissue. In recent years, it has been found that omentin protein has the functions of enhancing insulin sensitivity, anti-atherosclerosis, reducing inflammatory response, regulating vascular endothelial cell function, and cardiovascular protection, and is closely related to various clinical diseases such as diabetes, cardiovascular diseases, autoimmune diseases, and tumors. Therefore, it is particularly important to study the signaling pathways of omentin protein.