Parallel Lipoplex Folding Pathways by Magnetic tweezers (MT) (CAT#: STEM-MB-1267-WXH)

Introduction

Lipoplexes (cationic liposomes) are nonviral (synthetic) lipid carriers of DNA. Due to their positive surface charge, they may form complexes (spherical and continuous bilayer structures) with negatively charged DNA. Lipoplexes are a powerful gene delivery tool with promising therapeutic applications.

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Principle Applications Procedure Materials Notes Related Products

Principle

Magnetic tweezers (MT) are scientific instruments for the manipulation and characterization of biomolecules or polymers. These apparatus exert forces and torques to individual molecules or groups of molecules. It can be used to measure the tensile strength or the force generated by molecules.

Applications

Study of mechanical properties of biological macromolecules like DNA or proteins in single-molecule experiments.
Study of the rheology of soft matter.
Study of force-regulated processes in living cells.

Procedure

1.Sample preparation
2.Force Calibration
3.Measurement
4.Analysis

Materials

Magnetic tweezers

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