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Pyroptosis refers to the autonomous and orderly death of cells controlled by genes in order to maintain the stability of the internal environment. Pyroptosis is different from cell necrosis. Pyroptosis is not a passive process, but an active process. It involves the activation, expression and regulation of a series of genes. It is not a kind of autologous damage under pathological conditions. Phenomenon, but a process of death actively striving for better adaptation to the living environment.
Pyroptosis is a basic life phenomenon widely existing in the biological world, and it plays a very important role just like cell growth, development, and proliferation. At present, it is believed that the extracellular stimulus that induces pyroptosis must be transmitted through a series of intracellular signals, and the selective breakage of DNA between nucleosomes is one of its important signs.