Q Sepharose XL, 60 L, Cytiva (CAT#: STEM-C-1572-LC)

Q Sepharose XL manufactured by Cytiva is a strong anion exchanger with high loading capacities and excellent physical and chemical stability, ideal for capture steps of biomolecules from clarified feed-stocks. Q Sepharose XL is based on a highly cross-linked, bead formed 6% agarose matrix similar to the well established Q Sepharose Fast Flow resin. Dextran chains are covalently coupled to the agarose matrix and modified with quaternary ammonium (Q) strong anion exchange groups through chemically stable ether bonds. The stable agarose matrix and long, flexible chains of dextran with bound charged groups work together to increase loading capacity whilst allowing high flow rates.

BioProcess resin: Yes
Ligand: Quaternary amine
Particle size, d50V1: ~90 μm
Ion Exchanger Type: Strong anion exchanger
Matrix: 6% cross-linked agarose with dextran surface extenders
Particle Size: 45 μm-165 μm
Ligand Coupling Method: Dextran extenders through ether bonds
Ionic Capacity: 0.18-0.26 mmol Cl-/ml medium
pH stability, operational2: 2-12
pH stability, CIP3: 2-14
Pressure/Flow Specification: 300-500 cm/h
Storage: 4 to 30°C, 20% Ethanol
Chemical stability: Commonly used buffers, nonionic detergents, 1 M NaOH, 6 M guanidine hydrochloride
Certificate of Analysis: Yes
Licensing: For licensing information, see the Licensing Statements page in the About Us section.
Pack size: 60 L

High loading capacities give more productive capture from clarified feedstocks
High chemical stability for effective CIP/sanitization
The hydrophilic nature of the base matrix ensures low levels of non-specific binding leading to low levels of host cell-derived impurities in the elution pool

Capto MMC, 10 L, Cytiva (CAT#: STEM-C-1563-LC)