Performance
Measuring range: 0.4 ppb- 100.000 ppb
Measurement lower limit: 0.4ppb
Accuracy: <2% or 3ppb (whichever is greater)
Accuracy: ±2%
Calibration time: 90 minutes
Measurement time: <3% or 3 ppb (whichever is greater)
Drift between samples (from 500ppb → blank): < 0.2%
Over-range recovery (from 1000ppm→1ppm): 1 measurement can be recovered
Inorganic carbon treatment
Is an additional inorganic carbon removal module required when the concentration of inorganic carbon is high: No
Dynamic Endpoint Detection Guaranteed Complete Inorganic Carbon Removal: Yes
System self-diagnostics ensure data integrity
TOC measurement will stop under the following conditions: UV light intensity is too weak, carrier gas is insufficient/exhausted, reagent is insufficient/empty bottle, sample volume is insufficient/empty bottle
Reagent
Reagent source: Self-made or purchased from Hach
Types of reagents [acids, oxidizing agents, deionized water]: only one reagent for all measurements
Operation interface: display screen
10.4-inch high-resolution color touch screen
External computer: no external computer required
External keyboard/mouse: optional
Operability: Intuitive operation interface can guide users to measure
Measurement Methods and Guarantees
Oxidation method: UV lamp + persulfate
UV lamp: broadband silicon photodiode sensor
Detector: Digital NDIR
Detector stability: continuous confirmation with reference control
Detector moisture pre-cleaning: Peltier cooler. Continuous detection of flow
Dispenser Module: Syringe Pump, Accuracy +/-1%
Flow sensor: dynamic fluid sensor (to ensure accurate sample volume and reagent volume)
Type of carrier gas: (CO2-free) N, or O2
Carrier gas pressure measurement: dual hole pressure sensor
Carrier gas valve automatic closing function: when the measurement is completed, the valve will be closed to avoid wasting carrier gas
Auto-ranging function: Yes
Analysis Mode: NPOC (Non-Purgeable Organic Carbon)
Data storage and prosecution
Specification: 21 CFR part11. All measurements are recorded in encrypted database
Paperless report: FTP protocol Ethernet transmission
Output: 5 USB. One Ethernet port
Data output format: PDF, CSV
daily verification
Calibration: daily automatic calibration, 18-point calibration using KHP (6 concentrations, 3 replicate samples each)
Calibration solution: 5ppm KHP (125mL). Dilute to 1,2,3,4,5ppm concentration: reagent as blank
Validation Test/System Suitability USP System Suitability Bulk Water Set (Blank, 500ppb C-Sucrose, 500ppb C-Benzoquinone); USP System Suitability Sterile Water Set (Blank, 8ppm C-Sucrose.8ppm C-Benzoquinone); JP -16 <2.59> verification kit (blank 500ppb C-SDBS)
Compliance
Pharmacopoeia: USP<643> (including suitability test for sterile water system). JP-16 <2.59>. EP <2.2.44> , IP. CP. KP
US EPA: 5310c.415.3
21 CFR part 11: Compliance
ICH Guidelines for Instrument Validation including Accuracy, Precision, Limit of Detection LOD. Limit of Quantitation LOQ. Linearity, Range, Characterization, Stability: Compliance, included in I0/0Q
Autosampler
Maximum sample volume: 64 vials (standard 40mL glass TOC vials)
Style: XYZ triaxial. Diaphragm puncture
Sample tray material: anodized aluminum
General Technical Parameters
Instrument: Size: W320 * D507* H410 mm; Power: 100-240 VAC 47-63Hz; Weight: 10kg
Autosampler: Dimensions: W366*D537* H457 mm; Power: 100-240 VAC, 47-63H2z; Weight: 21kg
Operating environment: 10-35℃, maximum relative humidity 90% non-condensing
Measurement result unit: ug/L (ppb) or mg/L (ppm)