Rat Recombinant M-CSF, STEMCELL Technologies (CAT#: STEM-CT-1010-ZJF)

Macrophage colony-stimulating factor (M-CSF) is a homodimeric cytokine that belongs to receptor tyrosine kinase subclass III of the receptor tyrosine kinase (RTK) family. M-CSF acts on a CSF-1 receptor tyrosine kinase, which initiates signaling cascades to support cell proliferation and differentiation (Hamilton). M-CSF is produced by endothelial cells, osteoblasts, and during pregnancy by the uterine epithelial cells (Ryan). M-CSF synergizes with other factors to support proliferation and differentiation of multipotent hematopoietic progenitor cells, and regulates proliferation and differentiation of the mononuclear phagocyte progenitor cells to monocytes and macrophages. It also supports survival, proliferation, and function of the differentiated macrophages and regulates differentiation of mononuclear phagocytes to osteoclasts (Pixley & Stanley). M-CSF plays an important role in the implantation of the embryo and early development (Makrigiannakis et al.).

Subtype: Cytokines
Alternatives Names: CSF-1, Macrophage colony-stimulating factor
Cell Type: Hematopoietic Stem and Progenitor Cells, Monocytes
Species: Rat
Area of Interest: Immunology, Stem Cell Biology
Molecular Weight: 18 kDa
Purity: ≥ 95%

Reliable Consistency: Guarantees uniformity and repeatability in various applications with endotoxin levels below 0.2 EU/μg.
Free of Animal Components: Completely devoid of any animal or human-derived elements.
Broad Selection: Offers a wide range of human, mouse, and rat cytokines available in multiple sizes.

Mouse Recombinant VEGF-164, STEMCELL Technologies
Rat Recombinant GM-CSF, STEMCELL Technologies
Rat Recombinant TNF-alpha, STEMCELL Technologies
Recombinant B18R Protein, STEMCELL Technologies