Recombinant Human B7-H5 Protein, Seafrom (CAT#: STEM-CT-0126-ZJF)

The Recombinant Human B7-H5 Protein manufactured by Seafrom is suitable for T-cell co-stimulation and immune responses.
Platelet receptor Gi24, also known as B7-H5 and Stress-Induced Secreted Protein-1 (Sisp-1), is a protein encoded by the C10orf54 gene in the human body. It contains 1 Ig-like domain. Regarding the C10orf54 gene, it is positively correlated with BMP-4, enhancing BMP signaling and promoting the transition of ESCs from an undifferentiated state to a differentiated state. Human C10orf54 undergoes proteolytic cleavage via MT1-MMP, generating a soluble 30kDa extracellular fragment along with a 25-30kDa membrane-bound fragment.
Storage Information:
The lyophilized (freeze-dried) form can be stored at 4°C for 24 months, while the reconstituted liquid can be stored at -20°C for 6-12 months, with a recommendation to avoid repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Source: Human
Synonyms: B7-H5, SISP1, Gi24, VISTA
Protein Sequence: The DNA sequence encodes human B7-H5 (GenBank: AAH20568.1), expressed with a His tag at the C-terminus.
Molecular Weight: Recombinant human B7-H5 protein contains 116 amino acids, with a predicted theoretical molecular weight of 19.8 kD.
Purity: ≥95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis.
Endotoxin: <0.1 EU/μg
Biological Activity: Its activity was determined by measuring its ability to inhibit anti-CD3 monoclonal antibody-induced IL-2 secretion in human T lymphocytes. The ED50 for this effect is 1-6 μg/mL.
Purification Method: Chromatographic purification
Composition: Sterile PBS (pH 7.4) freeze-dried powder containing 6% mannitol.

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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