Recombinant Human B7-H7 Protein, Seafrom (CAT#: STEM-CT-0124-ZJF)

The Recombinant Human B7-H7 Protein manufactured by Seafrom is suitable for T-cell co-stimulation and immune responses.
B7-H7 (HHLA2) is a recently discovered member of the B7 family that regulates T cell function in the human body. B7-H7 was previously known as the Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 (HHLA2) with an unknown function. Recently, B7-H7 has been identified as the specific ligand for human CD28H. The B7-H7-CD28H pathway strongly promotes CD4+ T cell proliferation and cytokine production through AKT-dependent signaling cascades when TCR signaling is present, indicating that B7-H7 constitutes a novel co-stimulatory pathway. The first IgV domain of B7-H7 may interact with the putative receptor, demonstrating its highest homology with other B7 family members.
Storage Information:
The lyophilized (freeze-dried) form can be stored at 4°C for 24 months, while the reconstituted liquid can be stored at -20°C for 6-12 months, with a recommendation to avoid repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Source: Human
Synonyms: HHLA2, B7 Homolog 7
Protein Sequence: The DNA sequence encodes human B7-H7 (UniProtKB/Swiss-Prot: Q9UM44.1), expressed with an Fc tag at the C-terminus.
Molecular Weight: Recombinant human B7-H7 protein contains 554 amino acids, with a predicted theoretical molecular weight of 66.9 kD.
Purity: ≥95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis.
Endotoxin: <0.1 EU/μg
Biological Activity: The concentration of immobilized human B7-H7 (Fc tag) is 10 μg/mL (100 μL/well), and it can bind to human CD28H (His tag) in a linear range of 0.5-30 μg/mL.
Purification Method: Chromatographic purification
Composition: Sterile PBS (pH 7.4) freeze-dried powder containing 6% mannitol.

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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