Recombinant Human CD27 Ligand Protein, Seafrom (CAT#: STEM-CT-0141-ZJF)

The Recombinant Human CD27 Ligand Protein manufactured by Seafrom is suitable for T-cell co-stimulation and immune responses.
Differentiation Cluster 70 (CD70), also known as CD27 ligand (CD27L/CD27LG), TNFSF7, and TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF). It serves as a surface antigen for activated T cells, B cells, and mature dendritic cells. The binding of CD70 to its receptor CD27 induces the activation, effector functions, differentiation, and memory formation of T cells, thus playing a role in T cell activation, co-stimulation of T cell proliferation, and the generation of cytolytic T cells.
CD70 on T cells provides a co-stimulatory signal that is necessary for T cell proliferation, clonal expansion, and the promotion of effector T cell formation. On mouse B cells, CD70 has been shown to inhibit the terminal differentiation of activated B cells into plasma cells and enhance the commitment to memory B cell responses. CD70 on NK cells induces proliferation and IFN-γ production.
Storage information for lyophilized products: They can be stored at 4°C for 24 months, and the liquid after reconstitution can be stored at -20°C for 6-12 months, avoiding repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Source: Human
Synonyms: CD70, CD27LG, TNFSF7, TNFSF7G, CD27L
Protein Sequence: The DNA sequence encodes human CD27 Ligand (UniProtKB/Swiss-Prot: P32970.2), expressed with a His tag at the C-terminus.
Molecular Weight: Recombinant human CD27 Ligand contains 154 amino acids, with a predicted theoretical molecular weight of 18.8 kD.
Purity: ≥95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis.
Endotoxin: <0.1 EU/μg
Biological Activity: Immobilized human CD27 (FC tag) protein at a concentration of 1 μg/mL (100 μL/well) can bind to CD27 Ligand (His tag) in a linear range of 0.8-15 ng/mL.
Purification Method: Chromatographic purification
Composition: Sterile PBS (pH 7.4) freeze-dried powder containing 6% mannitol.

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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