Recombinant Human CD38 Protein, Seafrom (CAT#: STEM-CT-0152-ZJF)

The Recombinant Human CD38 Protein manufactured by Seafrom is suitable for immune cell activation and regulation.
CD38, also known as ADP-ribosyl cyclase 1, belongs to the ADP-ribosyl cyclase family. It is expressed at high levels in various tissues, including the pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma, and neuroblastoma. CD38 is a multifunctional ectoenzyme that plays a role in catalyzing the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular calcium levels.
CD38 has diverse functions and is associated with the regulation of immunological responses, metabolic processes, and behavior. The loss of CD38 function has been linked to impaired immune responses, metabolic disturbances, and behavioral modifications. CD38 is considered a marker of cell activation.
The CD38 protein has implications in various health conditions, including HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus, and bone metabolism. It has been used as a prognostic marker in leukemia.
The freeze-dried (lyophilized) form of CD38 can be stored at 4℃ for up to 24 months. Once reconstituted, the liquid can be stored at -20℃ for 6-12 months, with precautions taken to avoid repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Source: Human
Synonyms: ADPRC 1, ADPRC1, T10, cADPr hydrolase 1
Protein Sequence: The DNA sequence encodes human CD38 (UniProtKB/Swiss-Prot: Q01973), expressed with an Fc tag at the C-terminus.
Molecular Weight: Recombinant human CD38 protein contains 489 amino acids, with a predicted theoretical molecular weight of 56.8 kD.
Purity: ≥95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis.
Endotoxin: <0.1 EU/μg
Biological Activity: Immobilized human CD38 (Fc Tag) at 1 μg/mL (100 μL/well) can bind to humanized anti-CD38 antibody in a linear range of 1-5 ng/mL.
Purification Method: Chromatographic purification
Composition: Sterile PBS (pH 7.4) freeze-dried powder containing 6% mannitol.

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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