Recombinant Human GITR Protein, Seafrom (CAT#: STEM-CT-0150-ZJF)

The Recombinant Human GITR Protein manufactured by Seafrom is suitable for immune cell activation and responses.
Glucocorticoid-Induced TNFR-Related Protein (GITR), also known as Tumor Necrosis Factor Receptor Superfamily Member 18 (TNFRSF18), Activation-Inducible TNFR Family Receptor (AITR), and CD antigen CD357, is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR serves as the receptor for TNFSF18 (GITRL or GITR Ligand) and plays a role in interactions between activated T-lymphocytes and endothelial cells. Additionally, it is involved in the regulation of T-cell receptor-mediated cell death.
GITR mediates NF-kappa-B activation through the TRAF2/NIK pathway, contributing to the regulation of cellular processes. The freeze-dried (lyophilized) form of GITR can be stored at 4℃ for up to 24 months. Once reconstituted, the liquid can be stored at -20℃ for 6-12 months, with precautions taken to avoid repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Source: Human
Synonyms: AITR, TNFRSF18, CD357
Protein Sequence: The DNA sequence encodes human GITR (NCBI Reference Sequence: NP_683700.1), expressed with an Fc tag at the C-terminus.
Molecular Weight: Recombinant human GITR protein contains 368 amino acids, with a predicted theoretical molecular weight of 41.5 kD.
Purity: ≥95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis.
Endotoxin: <0.1 EU/μg
Biological Activity: Immobilized human GITR (Fc tag) at 5 μg/mL (100 μL/well) can bind to human GITR Ligand (His tag) in a linear range of 2-100 ng/mL.
Purification Method: Chromatographic purification
Composition: Sterile PBS (pH 7.4) freeze-dried powder containing 6% mannitol.

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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