Recombinant Human HVEM Protein, Seafrom (CAT#: STEM-CT-0112-ZJF)

The Recombinant Human HVEM Protein manufactured by Seafrom is suitable for immune regulation and signaling.
Herpesvirus entry mediator (HVEM), also known as TNFRSF14, TR2 (TNF receptor-like molecule), and ATAR (another TRAF-associated receptor), is a type I membrane protein that belongs to the TNF/NGF receptor superfamily. HVEM is expressed in peripheral blood T cells, B cells, monocytes, and various tissues enriched in lymphoid cells.
The extracellular domain of HVEM has been demonstrated to directly interact with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been identified as the cellular ligands for HVEM. Furthermore, LIGHT can also interact with LTβR, which is the receptor for the lymphotoxin αβ heterotrimer.
The precise role of the HVEM LIGHT / LTβ receptor ligand pair in immune function and herpesvirus pathobiology is yet to be fully understood.
Storage Information:
Lyophilized samples can be stored at 4°C for 24 months. Once reconstituted, the liquid can be stored at -20°C for 6-12 months, with care taken to avoid repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Source: Human
Synonyms: TNFRSF14, ATAR, HVEA, LIGHTR, TR2, CD270
Protein Sequence: The DNA sequence encodes human HVEM (UniProtKB/Swiss-Prot: Q01973), expressed with an Fc tag at the C-terminus.
Molecular Weight: Recombinant human HVEM protein contains 468 amino acids, with a predicted theoretical molecular weight of 51.3 kD.
Purity: ≥95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis.
Endotoxin: <0.1 EU/μg
Biological Activity: The ability to bind to human HVEM (Fc tag) is confirmed by fixing LIGHT (His tag) at 5 μg/mL (100 μL/well), with a linear range of 50-200 ng/mL.
Purification Method: Chromatographic purification
Composition: Sterile PBS (pH 7.4) freeze-dried powder containing 6% mannitol.

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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