Recombinant Human IL-36RA Protein, Seafrom (CAT#: STEM-CT-0069-ZJF)

The Recombinant Human IL-36RA Protein manufactured by Seafrom is suitable for studying anti-inflammatory effects and immune responses.
The IL-1 family consists of 11 structurally related ligands, including the recently renamed IL-36RA (IL-1F5), IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9). Interaction between IL-36 ligands and the IL-1Rrp2 receptor (IL-1R6) induces the maturation and activation of dendritic cells. IL-36RA, by binding to the IL-1Rrp2 receptor, antagonizes the NF-RrpB signaling induced by IL-36α, β, or γ, thereby preventing the initiation of functional signaling.
The lyophilized formulation can be stored at 4°C for up to 24 months. Once reconstituted, the liquid can be stored at -20°C for 6-12 months, and it is important to avoid repeated freeze-thaw cycles.

Expression Host: Human HEK293 Cells
Synonyms: Interleukin-36RA, FIL1 delta, IL-1F5, IL-1HY1, IL-1L1, IL-1RP3, IL-1ra Homolog 1, IL-1delta, IL36RN
Protein Sequence: DNA sequence encodes human IL-36RA (NP_036407.1) with a His tag at the C-terminus, contains 160 amino acids, predicted molecular weight of 17.7 kD
Purity: ≥95%, analyzed by SDS-PAGE and HPLC
Endotoxin Level: ≤0.01 EU/μg (gel clot method)
Biological Activity: Inhibition of IL-36γ-induced IL-8 secretion in A431 cells
Purification Method: Chromatographic purification

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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