Recombinant Rat M-CSF Protein, Seafrom (CAT#: STEM-CT-0037-ZJF)

The Recombinant Rat M-CSF Protein manufactured by Seafrom is suitable for growth and differentiation of monocytes and macrophages.
Macrophage Colony-Stimulating Factor (M-CSF) is a potent hematopoietic growth factor produced by various cells, including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts, and osteoblasts. It plays a critical role in regulating the proliferation, differentiation, and survival of blood monocytes, tissue macrophages, and their respective progenitor cells. M-CSF is essential in modulating dermal thickness and fertility. In clinical applications, M-CSF is used for the treatment of infections, malignant tumors, and atherosclerosis. It also promotes the recovery of hematopoietic function following bone marrow transplantation.
While human M-CSF is reactive in mouse systems, its molecules do not exhibit activity in human cells.
The lyophilized product can be stored at 2-8°C for 24 months. For reconstitution, it can be dissolved in injectable water, saline solution, culture medium, or PBS. After dissolution, it should be aliquoted, with a recommended storage period of 6 months at -20°C and 12 months at -80°C. When diluting, ensure a final concentration of no less than 100μg/mL and avoid repeated freeze-thaw cycles.

Expression Host: HEK293 Cells
Synonyms: Macrophage Colony-Stimulating Factor, CSF-1, MGI-IM
Protein Sequence: DNA sequence encodes rat M-CSF (NP_076471.3) with a His tag at the C-terminus, predicted molecular weight of 18.8 kD
Purity: >90%, analyzed by SDS-PAGE
Endotoxin Level: <1 EU/μg
Biological Activity: ED50 determined by dose-dependent stimulation of mouse M-NFS-60 cell proliferation is ≤ 5.0 ng/mL, corresponding specific activity is ≥2x10^5 IU/mg
Purification Method: Chromatographic purification
Appearance: White loose body

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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