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Angiotensin-II-receptor antagonists (ARA-IIs) are safe and effective agents for the treatment of hypertension and heart failure, either alone, or in conjunction with hydrochlorothiazide (HCT), a thiazide diuretic. They have been proposed as an alternative to the more traditional angiotensin-converting enzyme inhibitors, because they selectively block the angiotensin type 1 (AT1) receptor, which is responsible for vasoconstriction, and they prevent salt and water retention. This service provides zone electrophoretic (CZE) and micellar electrokinetic capillary chromatographic (MEKC) methods to simultaneously separate hydrochlorothiazide and six angiotensin-II-receptor antagonists (ARA-IIs): candesartan, eprosartan mesylate, irbesartan, losartan potassium, telmisartan, and valsartan.