Sleep Deprivation Animal Model (CAT#: STEM-AE-0030-WXH)

Introduction

Sleep plays a very important physiological role in the life activities of humans and mammals. So far, the exact mechanism of sleep has not been fully elucidated. Sleep deprivation is an important method to study the function and mechanism of sleep. Methods for making sleep deprivation models include platform sleep deprivation method (using rats' habit of fear of water and inability to sleep in water), forced exercise method, gentle stimulation method, drug sleep deprivation method.

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Principle Applications Procedure Materials Notes Related Products

Applications

• Mechanisms related to sleep
• Drug development, drug screening and efficacy research

Procedure

• Platform sleep deprivation method: Place a platform in a tank of water with a diameter small enough for the rat to stand on.
• Forced exercise-water turntable method: Rats adapt to the box for a period of time, pour water under the box inside the box, start the power device to make the turntable rotate at a constant speed, and rats must stay awake to avoid falling into the water.
• Gentle stimulation method: Keep rats awake by gently tapping the cage or using stimuli such as sound and light.
• Drug injection method: mostly central nervous system stimulants.

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