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Bone is one of the most important biological structures in the field of biomineralization. From the viewpoint of a materials scientist, bone is a composite of an organic and an inorganic phase with highly hierarchical structure. Its main building blocks are long collagen fibrils of about 100-nm diameter that contain nanometer-sized carbonated apatite crystals. There is a clear relationship between the weight fraction of the mineral phase in bone and its mechanical properties. The skeletal system in vertebrates is subject to continuous dissolution and formation by osteoclasts and osteoblasts.