Because of the recent progress in intense laser technology, the advanced PW class lasers can now achieve intense laser fields around 1022 W/cm2; with such fields, all the electrons inside the micron-size hydrogen cluster up to 3.0 µm in diameter can be fully stripped off, resulting in a pure Coulomb explosion with a pronounced increase in accelerated maximum proton energies scaled as Emax = 276(d/2)2, where d is a diameter of clusters. For example, 100 MeV protons could be produced via the Coulomb explosion of the 1.2 µm diameter hydrogen cluster when irradiated by a laser pulse with a peak intensity of 1.6 × 1021 W/cm2. The robust nature of the Coulomb explosion mechanism offer an additional advantage for practical applications. Therefore, production of micron-size hydrogen cluster with sizes of a few µm range has been a critical issue to generate pure proton beams exceeding 100 MeV.