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Histamine is a chemical immune system releases. It's mainly known for its role in causing allergy symptoms. But it has other important functions, like regulating sleep-wake cycle and cognitive function. Antihistamines are a common medication that can manage histamine levels.
It can be found in most of the tissues of the body, but is in higher concentrations in the lungs, skin and the gut. Usually found in basophils and mast cells. Released from mast cells during inflammatory or allergic reactions.