Study of Kinetics of sickle hemoglobin polymerization (CAT#: STEM-AC-0073-WXH)

Introduction

Sickle cell disease is particularly common in people with an African or Caribbean family background. People with sickle cell disease produce unusually shaped red blood cells that can cause problems because they do not live as long as healthy blood cells and can block blood vessels.
The pathology of sickle cell disease is caused by polymerization of the abnormal hemoglobin S upon deoxygenation in the tissues to form fibers in red cells, causing them to deform and occlude the circulation.

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Principle Applications Procedure Materials Notes Related Products

Principle

The temperature jump method is a technique used in chemical kinetics for the measurement of very rapid reaction rates.
The T-Jump technique provides a means to follow fast reactions with half-lives of just a few microseconds. The reaction volume is prepared so that it is in equilibrium and then rapidly perturbed by a rapid change in temperature. There is a new equilibrium constant at the higher temperature, but the initial concentrations are balanced for the lower temperature. The system therefore relaxes and the reaction proceeds until the concentrations have reached their new equilibrium values.

Applications

Used in chemical kinetics for the measurement of very rapid reaction rates

Materials

Temperature Jump System

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