Study of Oxidative chemistry of peroxynitrite by Quench-Flow method (CAT#: STEM-AC-0050-WXH)

Introduction

Peroxynitrite is not a free radical because the unpaired electrons on nitric oxide and superoxide have combined to form a new N–O bond in peroxynitrite. Peroxynitrite anion can be stored for weeks in alkaline solution or even entrapped in solid forms. During its decomposition at physiological pH, peroxynitrite can produce some of the strongest oxidants known in a biological system, initiating reactions characteristic of hydroxyl radical, nitronium ion, and nitrogen dioxide. The unusual stability of peroxynitrite as an anion contributes to its toxicity by allowing it to diffuse far from its site of formation while being selectively reactive with cellular targets.