Study of the effect of Trimethylamine N-oxide (TMAO) on protein by Magnetic tweezers (MT) (CAT#: STEM-MB-1276-WXH)

Introduction

Trimethylamine N-oxide (TMAO) is an organic compound with the formula (CH3)3NO. TMAO is found in the tissues of marine crustaceans and marine fish, where it prevents water pressure from distorting proteins and thus killing the animal.
TMAO is a well-known osmolyte to stabilize the folded proteins through a variety of mechanisms. Since mechanical strength of proteins is a critical determinant of its stabilization, TMAO might play a relevant role by favoring its folding dynamics or by enhancing its mechanical stability.