Study of the Viscoelastic Properties of Fibrin Clots by Magnetic tweezers (MT) (CAT#: STEM-MB-1272-WXH)

Introduction

Fibrin clots are meant to be temporary structures formed to stop bleeding. After the process of wound healing has started, the ridged clot must be broken down to reduce the risk of thrombosis. The process of clot breakdown or fibrinolysis is orchestrated by the plasmin system.

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Principle Applications Procedure Materials Notes Related Products

Principle

Magnetic tweezers (MT) are scientific instruments for the manipulation and characterization of biomolecules or polymers. These apparatus exert forces and torques to individual molecules or groups of molecules. It can be used to measure the tensile strength or the force generated by molecules.

Applications

Study of mechanical properties of biological macromolecules like DNA or proteins in single-molecule experiments.
Study of the rheology of soft matter.
Study of force-regulated processes in living cells.

Procedure

1.Sample preparation
2.Force Calibration
3.Measurement
4.Analysis

Materials

Magnetic tweezers

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