Study the Binding of anti-cancer chemotherapeutic drug mitoxantrone to DNA by Magnetic tweezers (MT) (CAT#: STEM-MB-1256-WXH)

Introduction

Chemotherapeutic agents (anti-cancer drugs) are small cytostatic or cytotoxic molecules that often bind to double-stranded DNA (dsDNA) resulting in modifications of their structural and nanomechanical properties and thus interfering with the cell proliferation process.

Add to Cart Please Inquire

Principle Applications Procedure Materials Notes Related Products

Principle

Magnetic tweezers (MT) are scientific instruments for the manipulation and characterization of biomolecules or polymers. These apparatus exert forces and torques to individual molecules or groups of molecules. It can be used to measure the tensile strength or the force generated by molecules.

Applications

Study of mechanical properties of biological macromolecules like DNA or proteins in single-molecule experiments.
Study of the rheology of soft matter.
Study of force-regulated processes in living cells.

Procedure

1.Sample preparation
2.Force Calibration
3.Measurement
4.Analysis

Materials

Magnetic tweezers

Other recommended products

Measurement of torsional stiffness in RecA-DNA filaments by Magnetic tweezers (MT) (CAT#: STEM-MB-1277-WXH)
Study of IgCAMs by Magnetic tweezers (MT) (CAT#: STEM-MB-1261-WXH)
Study of Type IB Topoisomerases by Magnetic tweezers (MT) (CAT#: STEM-MB-1245-WXH)
Study of DNA packing by a cationic lipid DSTAP by Magnetic tweezers (MT) (CAT#: STEM-MB-1268-WXH)
Parallel Lipoplex Folding Pathways by Magnetic tweezers (MT) (CAT#: STEM-MB-1267-WXH)
Study of DNA-Protein Interactions by Magnetic tweezers (MT) (CAT#: STEM-MB-1273-WXH)
Study of the dynamic activity of polymerases by Magnetic tweezers (MT) (CAT#: STEM-MB-1233-WXH)
Study of the Viscoelastic Properties of Fibrin Clots by Magnetic tweezers (MT) (CAT#: STEM-MB-1272-WXH)