Acute Myocardial Infarction Animal Model (CAT#: STEM-AE-0041-WXH)

Introduction

Acute myocardial infarction (AMI) seriously endangers the health of human beings all over the world and has become one of the leading causes of death. At present, the most effective treatment for AMI is coronary artery reperfusion, but it is also accompanied by the problem of reperfusion injury. The research on myocardial ischemia-reperfusion injury has become one of the hot issues in the world. The survival rate of rats and the success rate of modeling after rat myocardial ischemia-reperfusion injury (MIRI) modeling are one of the key factors restricting the study of simulated clinical cardiovascular and pharmacological effects.

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Principle Applications Procedure Materials Notes Related Products

Applications

• Study the pathogenesis and treatment of myocardial infarction.
• Drug development, drug screening and efficacy research.

Procedure

• Ligation of the left anterior descending coronary artery:
1. Anesthetizing and Lifting the Hair.
2. Intubation.
3. Expose the left anterior descending coronary artery.
4. Ligation of Coronary Arteries.
5. Chest closure and postoperative management.
• Chemical injection methods (such as isoproterenol)

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